insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide
Sample solution is provided at 25 µL, 10mM.
Publications citing ApexBio Products
|Cas No.||131929-60-7||SDF||Download SDF|
|Canonical SMILES||CN(C)[[email protected]]1CC[[email protected]@](O[[email protected]]([[email protected]@H](C)C2=O)CCC[[email protected]](CC)OC(C[[email protected]]3([H])C2=C[[email protected]]4([H])[[email protected]@]3([H])C=C[[email protected]@]5([H])[[email protected]@]4([H])C[[email protected]](O[[email protected]]6([H])O[[email protected]@H](C)[[email protected]](OC)[[email protected]@H](OC)[[email protected]]6OC)C5)=O)([H])O[[email protected]@H]1C|
|Solubility||Soluble in DMSO||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.
The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.
In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A .
In vivo: Currently, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
 L. C. Creemer, H. A. Kirst, J. W. Paschal, et al. Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. J.Antibiot.(Tokyo) 53(2), 171-178 (2000).