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Spinosyn A
insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide

Spinosyn A

Catalog No. C3592
Size Price Stock Qty
1mg $225.00 In stock
5mg $799.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Spinosyn A

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Chemical Properties

Cas No. 131929-60-7 SDF Download SDF
Synonyms A-83543A|Lepicidin A
Chemical Name (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,
Canonical SMILES CN(C)[C@H]1CC[C@@](O[C@H]([C@@H](C)C2=O)CCC[C@H](CC)OC(C[C@]3([H])C2=C[C@]4([H])[C@@]3([H])C=C[C@@]5([H])[C@@]4([H])C[C@H](O[C@]6([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]6OC)C5)=O)([H])O[C@@H]1C
Formula C41H65NO10 M.Wt 732.0
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.

The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.

In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

[1] L.  C. Creemer, H. A. Kirst, J. W. Paschal, et al. Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. J.Antibiot.(Tokyo) 53(2), 171-178 (2000).