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EGFR

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

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  1. Afatinib (BIBW2992)
    A8247 Afatinib (BIBW2992)
     1 Citation
    Target: EGFR
    Summary: Irreversible EGFR/HER2 inhibitor
      ≥24.3 mg/mL
  2. WZ4002
    A1389 WZ4002
    Summary: Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent
      ≥24.7 mg/mL
  3. CP-724714
    A2412 CP-724714
    Target: VEGFR|PDGFR|Bcr-Abl|Src|EGFR|c-MET|Insulin Receptors|IRG-1R
    Summary: HER2 inhibitor,potent and selective
      ≥23.5 mg/mL
  4. Pelitinib (EKB-569)
    A1835 Pelitinib (EKB-569)
    Summary: EGFR inhibitor,potent and irreversible
      insoluble in EtOH; insoluble in H2O; ≥11.7 mg/mL
  5. WZ8040
    A1393 WZ8040
    Target: EGFR
    Summary: EGFR T790M inhibitor,irreversible amd potent
      ≥24.05 mg/mL
  6. AC480 (BMS-599626)
    A2822 AC480 (BMS-599626)
    Target: EGFR
    Summary: HER1/2 inhibitor,selective and efficacious
      ≥28.35 mg/mL
  7. Canertinib (CI-1033)
    A1845 Canertinib (CI-1033)
    Summary: HER family tyrosine kinase inhibitor
  8. AEE788 (NVP-AEE788)
    A5455 AEE788 (NVP-AEE788)
    Summary: EGFR/HER-2/VEGFR inhibitor
      ≥22.05 mg/mL
  9. PD168393
    A2024 PD168393
    Target: PDGFR|FGFR|EGFR|PKC|insulin
    Summary: EGFR inhibitor
  10. AG-18
    A1173 AG-18
    Summary: EGFR/PDGFR inhibitor

Items 21-30 of 41

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