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Signaling Pathways

Signaling Pathways

B4655 BMS-345541(free base)

Summary: IKK-1/IKK-2 inhibitor,potent and selective

insoluble in H2O; ≥70 mg/mL
A2604 Celastrol

Target: Proteasome

Summary: Antioxidant, anti-inflammatory and immunosuppressive agent

≥22.55 mg/mL
A4210 Bay 11-7821 (BAY 11-7082)
1 Citation

Summary: IKK/NF-κB/TNFα inhibitor

insoluble in H2O; ≥64 mg/mL
A4217 QNZ (EVP4593)
2 Citation

Summary: Potent NF-κB inhibitor
A3220 Bardoxolone

Target: COX|iNOS

Summary: Once-a-day treatment for CKD

≥49.2 mg/mL
A3248 BMS345541 hydrochloride

Target: IKK

Summary: IKK inhibitor,highly selective

insoluble in EtOH; insoluble in DMSO; ≥60 mg/mL
A3485 IKK-2 inhibitor VIII

Summary: IKK-2 inhibitor,potent and selective

Soluble in DMSO
B5551 Poly(I:C)

Target: Toll-like receptors (TLRs)

Summary: Toll-like receptor 3 (TLR3) agonist

insoluble in DMSO; insoluble in EtOH; ≥21.5 mg/mL
N1831 Luteolin

Target: AP-1|MMP|15-lipoxygenases

Summary: Antioxidant and free radical scavenger
N1846 Tanshinone IIA

Target: AP-1|MAGL

Summary: Antioxidant and anti-inflammatory reagent

insoluble in EtOH; insoluble in H2O; ≥3.42 mg/mL