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Signaling Pathways

Items 11-20 of 102

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  1. TG101348 (SAR302503)
    A4136 TG101348 (SAR302503)
     2 Citation
    Target: FLT3|JAK|c-RET
    Summary: JAK-2 inhibitor,potent and selective
      ≥26.23 mg/mL
  2. AZD1480
    A4137 AZD1480
    Target: JAK
    Summary: JAK2 inhibitor,ATP-competitive and novel
      insoluble in H2O; ≥93.8 mg/mL
  3. WP1066
    A4140 WP1066
    Target: STAT|JAK
    Summary: JAK2/STAT3 inhibitor,cell-permeable
      insoluble in H2O; ≥17.8 mg/mL
  4. AZ 960
    A4144 AZ 960
    Target: JAK
    Summary: JAKs inhibitor
      Soluble in DMSO
  5. LY2784544
    A4147 LY2784544
    Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3K
    Summary: JAK2 inhibitor,highly potent and selective
      ≥23.5 mg/mL
  6. S-Ruxolitinib (INCB018424)
    A4149 S-Ruxolitinib (INCB018424)
    Target: JAK
    Summary: JAK1/2 inhibitor,potent and selective
      Soluble in DMSO
  7. WHI-P154
    A4150 WHI-P154
    Target: VEGFR|Src|EGFR|JAK
    Summary: JAK3 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥125.6 mg/mL
  8. A-966492
    A4160 A-966492
    Target: PARP
    Summary: PARP-1/-2 inhibitor, highly potent
      ≥32.4 mg/mL
  9. UPF 1069
    A4163 UPF 1069
    Target: PARP
    Summary: Selective PARP2 inhibitor
      insoluble in H2O; ≥12.7 mg/mL
  10. Entacapone
    A4168 Entacapone
    Target: Catechol O-Methyltransferase (COMT)
    Summary: COMT inhibitor

Items 11-20 of 102

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Category
  1. Bromodomain7item
  2. Aurora Kinase17item
  3. DNA Methyltransferase2item
  4. HDAC29item
  5. Histone Acetyltransferases3item
  6. Histone Demethylases3item
  7. Histone Methyltransferase8item
  8. HIF3item
  9. JAK14item
  10. PARP6item
  11. Pim2item
  12. Protein Ser/Thr Phosphatases3item
  13. Sirtuin4item
  14. Sphingosine Kinase-21 item
Specificity
  1. Selective64item
Reversibility
  1. Reversible4item
  2. Irreversible2item
Target
  1. Cyclin-Dependent Kinases1 item
  2. Histone Deacetylases (HDACs)25item
  3. Aurora Kinases17item
  4. MDM21 item
  5. EZH21 item
  6. Bromodomains5item
  7. FLT35item
  8. PLK1 item
  9. VEGFR3item
  10. RET1 item
  11. Hydrolase1 item
  12. MEK1 item
  13. DOT1L1 item
  14. FGFR2item
  15. Pim2item
  16. Sir2-like Family Deacetylases (Sirtuins)3item
  17. PP11 item
  18. PP2A1 item
  19. Src5item
  20. Trk Receptors1 item
  21. STAT2item
  22. EGFR2item
  23. Hypoxia Inducible Factors (HIFs)1 item
  24. JAK15item
  25. Syk1 item
  26. Topoisomerases1 item
  27. ErbB1 item
  28. DNA Methyltransferases2item
  29. LRRK21 item
  30. PARP6item
  31. ALK1 item
  32. phosphatases1 item
  33. COX1 item
  34. G9a1 item
  35. Hck1 item
  36. Histone Demethylases1 item
  37. MNK1 item
  38. AChE1 item
  39. Catechol O-Methyltransferase (COMT)1 item
  40. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  41. Protein Arginine Methyltransferases1 item
  42. Cytidine deaminases1 item
  43. PP41 item
  44. c-RET1 item
  45. VEGFR3/FLT41 item
  46. NTRK1/TRKA1 item
  47. CSF-1R/c-Fms1 item
  48. PTP1 item
  49. Protein polybromo-11 item
  50. SMARCA41 item
  51. SMARCA21 item
  52. p532item
  53. HDAC2item
  54. KDM2item
  55. LOX1 item
  56. Adenylyl cyclase1 item
  57. Quinone reductase1 item
  58. Histone Acetyltransferases (HATs)2item
  59. Trx1 item
  60. HIF-PH1 item
  61. L3MBTL1 item
  62. TYK22item
  63. MUSK1 item
  64. MAP3K1 item
  65. Lck1 item
  66. p211 item
  67. 5-HT1 item
  68. PHF1 item
  69. FGR1 item
  70. YES1 item
  71. Fyn1 item
  72. ARG1 item
  73. LSD1 item
  74. PRMT1 item
  75. GLP1 item
  76. SK1 item
  77. Sirtuin1 item
Related Disease
  1. Acute Myelogenous Leukemia2item
  2. Acute Myeloid Leukemia7item
  3. Bladder Cancer2item
  4. Bladder Carcinoma1 item
  5. Breast Cancer11item
  6. Cancer55item
  7. Castration-resistant Prostate Cancer1 item
  8. Cervical Cancer1 item
  9. Chronic Lymphocytic Leukemia1 item
  10. Colon Cancer4item
  11. Colorectal Cancer3item
  12. Diabetes1 item
  13. Diffuse Large B-cell Lymphoma1 item
  14. Dyskinesia1 item
  15. Epilepsy1 item
  16. Friedreich's Ataxia1 item
  17. Glioblastoma2item
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  19. HIV1 item
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  21. Inflammatory Diseases1 item
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  24. Lymphoma4item
  25. Melanoma2item
  26. Mixed Lineage Leukemia1 item
  27. Multiple Myeloma3item
  28. Myelofibrosis1 item
  29. Neuroblastoma2item
  30. Neuronal Protection1 item
  31. Non-small Cell Lung Cancer3item
  32. Ovarian Cancer3item
  33. Pancreatic Cancer3item
  34. Prostate Cancer7item
  35. Psoriasis1 item
  36. Renal Cancer1 item
  37. Renal Cell Carcinoma1 item
  38. Rheumatoid Arthritis2item
  39. Thyroid Cancer1 item
  40. Type 2 Diabetes1 item