MIP-3beta, murine recombinant protein
Catalog No.
P1049
MIP-3β, chemokine, expressed in E.Coli.
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Macrophage inflammatory protein-3 β (MIP-3β) is a CC chemokine produced in the thymus, lymph nodes and activated bone marrow stromal cells. MIP-3β signals through the chemokine receptor CCR-7/EBI-1/BLR-2. MIP-3β is a chemoattractant for T and B lymphocytes, and myeloid progenitor cells. The expression of MIP-3β is down-regulated by the anti-inflammatory cytokine IL-10. CCL19 and CCL21 control survival, apoptosis, migratory speed, and maturation of dendritic cells, rate of endocytosis and the cytoarchitecture.
The murine MIP-3β cDNA encodes a 108 aa protein contains a 25 aa signal sequence. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues.
| Determined by its ability to chemoattract human mature dendritic cells using a concentration of 10-100 ng/ml. |
Quality Control & DataSheet
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Purity: ≥98%, by SDS-PAGE and HPLC.
Endotoxin Level:< 0.1 ng/μg/span>
| Gene ID: | 24047 | Accession #: | O70460 |
| Alternate Names: | Murine MIP-3 beta; Recombinant Murine Macrophage Inflammatory Protein-3 beta/CCL19; Beta-chemokine Dxodus-3; CK beta-11; EBI1 Ligand Dhemokine; ELC Macrophage Inflammatory Protein 3 beta | ||
| Source: | Escherichia Coli. | M.Wt: | 9.2 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Lyophilized with no additives. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||