2-MPMDQ

2-MPMDQ is a potent and selective antagonist of α1-adrenoceptor [1].

α1-adrenoceptor is a G protein-coupled receptor and mediates noradrenaline and adrenaline signal in the central and peripheral nervous systems. Also, α1-adrenoceptor mediates smooth muscle contraction.

2-MPMDQ is a potent and selective α1-adrenoceptor antagonist. In spontaneously hypertensive rats, 2-MPMDQ showed antihypertensive activity [1].

Reference:
[1].  Chern JW, Tao PL, Yen MH, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem, 1993, 36(15): 2196-2207.