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Ruthenium Red

Catalog No.
Blocks Ca2+ uptake and release, and voltage-sensitive Ca2+ channels
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Ruthenium red is a strong inhibitor of Ca2+ transport in mitochondrial, in erythrocyte membrane and in sarcoplasmic reticulum (SR) of rabbit skeletal muscle, with the Km of 4.5 μM and 2.0 mM for the two Ca2+-binding sites [1].

By kinetic experiments, there are two high-affinity Ca2+-binding sites face the cytoplasmic portion of the SR membranes, which are located in helical segments clustered in the transmembrane domain of Ca2+-ATPase, forming a Ca2+ channel.

SR vesicles were incubated with 10 μM-45Ca2+ and various ruthenium red concentrations for 15 min before being filtered for 45Ca counting. The titration curve of Ca2+ binding showed two well-differentiated saturating effects with the Km of 4.5 μM and 2.0 mM for the two Ca2+-binding sites. The ability of SR vesicles to bind Ca2+ was decreased by micromolar ruthenium red concentrations [1].

In the investigation of the ability of inhibiting caspsaicin-induced plasma extravasation in the rat trachea, ruthenium red can reduce the amount of plasma extravasation in dose-dependently, with a dose of 5 μmol/kg of completely inhibiting [2].


[1] Corbalan-Garcia S, Teruel J A, Gomez-Fernandez J C. Characterization of Ruthenium Red-binding sites of the Ca2+-ATPase from sarcoplasmic reticulum and their interaction with Ca2+-binding sites [J]. Biochem J. 1992, 287(3): 767-774.

[2] Brokaw J J, White G W. Characterization of Ruthenium Red as an Inhibitor of Neurogenic Inflammation in the Rat Trachea [J]. Gen Pharmac. 1995, 26(2): 327-331.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
Cas No.11103-72-3
Solubilityinsoluble in DMSO; insoluble in EtOH; insoluble in H2O
SDFDownload SDF
Canonical SMILES[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[O].[O].[Ru+2].[Ru+2].[Ru+2]
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Related Biological Data

Ruthenium Red