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Ribosomal protein L3 peptide (202-222) amide

Catalog No.
A1088
HIV-1 TAR RNA-binding protein
Grouped product items
SizePriceStock Qty
1mg
$70.00
In stock
5mg
$210.00
In stock
10mg
$350.00
In stock
25mg
$490.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Ribosomal protein L3 peptide (202-222),(C114H182N42O25S), a peptide with the sequenceH2N-Met-Ser-His-Arg-Lys-Tyr-Glu-Ala-Pro-Arg-His-Gly-His-Leu-Gly-Phe-Leu-Pro-Arg-Lys-Arg-amide, MW=2573. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information(1).Ribosomal protein L3 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase centre of the ribosome(2). This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation(3).

 A1088_1

Figurestructure of Ribosomal protein L3

A1088_2 

Figure2  Proteins Networks for RPL3

Ref:

1. Ou JH, Yen TS, Wang YF, Kam WK, Rutter WJ (Jan 1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res 15 (21): 8919–34.

2. Kenmochi N, KawaguchiT, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, PageDC(May 1998). "A Map of 75 Human Ribosomal Protein Genes". Genome Research 8 (5): 509–523.

3. Van Raay TJ, Connors TD, Klinger KW et al. (1997). "A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region". Genomics 37 (2): 172–6.

 

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt2573
FormulaC114H182N42O25S
SynonymsH2N-Met-Ser-His-Arg-Lys-Tyr-Glu-Ala-Pro-Arg-His-Gly-His-Leu-Gly-Phe-Leu-Pro-Arg-Lys-Arg-amide
Solubility≥257.3 mg/mL in DMSO; ≥26.65 mg/mL in EtOH with ultrasonic; ≥45.5 mg/mL in H2O
SDFDownload SDF
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Ribosomal protein L3 peptide (202-222) amide