Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
- Cat.No. Product Name Information
WEHI-539 is a small-molecule inhibitor of BCLXLwith an IC50 value of 1.1 nM .
- B6094 BH3I-1
S63845 is a small molecule MCL1 inhibitor with Ki < 1.2 nM .
- B6011 A-1210477
- B5978 BDA-366 BDA-366 is a selective antagonist of BCL2 BH4 domain with Ki value of 3.3 nM .
- B5846 Radotinib(IY-5511) Radotinib(IY-5511) is a novel and selective Bcl-Abl tyrosine kinase inhibitor. 
- B4902 (+)-Apogossypol
- B4901 Pyridoclax
- B4881 UMI-77
- A9902 Bcl Family Set I ABT-737 is a BH3 mimetic inhibitor of Bcl-xL (EC50=78.7 nM), Bcl-2 (EC50=30.3 nM) and Bcl-w (EC50=197.8 nM), respectively.