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Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

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  1. Cat.No. Product Name Information
  2. B4902 (+)-Apogossypol inhibitor of Bcl-2 family proteins
  3. A4447 2,3-DCPE hydrochloride Bcl-XL protein expression downregulator
  4. B6011 A-1210477 MCL-1 inhibitor
  5. A8194 ABT-199 Bcl-2 inhibitor,potent and selective
  6. A3007 ABT-263 (Navitoclax) Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
  7. A8193 ABT-737 Bcl-2 inhibitor
  8. A4200 Apogossypolone (ApoG2) Bcl-2 inhibitor,nonpeptidic small molecule
  9. A3196 AT-101 BH3-mimetic,gossypol enantiomer
  10. A3218 BAM7 BAX activator,direct and selective
  11. A4459 Bax channel blocker Inhibitor of Bax-mediated mitochondrial cytochrome c release

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