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Apoptosis Activator 2
Indoledione caspase activator, cell-permeable

Catalog No.A4016
Size Price Stock Qty
10mg
$50.00
In stock
25mg
$100.00
In stock
50mg
$180.00
In stock
100mg
$280.00
In stock

Tel: +1-832-696-8203

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Apoptosis Activator 2

Biological Activity

Description Apoptosis Activator 2 is a cell-permeable indoledione activator of caspases with IC50 value of 4-9 μM for leukemia cells.
Targets caspase          
IC50            

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Chemical Properties

Cas No. 79183-19-0 SDF Download SDF
Chemical Name 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Canonical SMILES C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
Formula C15H9Cl2NO2 M.Wt 306.1
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
Physical Appearance A crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4μM [1].

Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. It is found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation. Moreover, this induction of apoptosis only occurs in tumor cell lines (such as breast, lung, colon, and epidermal cancer cell lines). Normal cell lines are resistant to Apoptosis Activator 2 [1, 2].

References:
[1] Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.
[2] Nguyen TV, Jayaraman A, Quaglino A, Pike CJ. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22.