Toggle Nav
Close
  • Menu
  • Setting

Recombinant Human IL-6, Tag Free

Catalog No.
PH1001
 
Grouped product items
SizePriceStock Qty
10ug
$71.00
Ship with 5-10 days
50ug
$210.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Interleukin-6 (IL-6) is a multifunctional alpha-helical cytokine that regulates cell growth and differentiation of various tissues and is particularly known for its role in immune responses and acute phase responses. IL-6 protein is a phosphorylated and variably glycosylated molecule secreted by a variety of cell types, including T cells and macrophages. It acts through its heterodimeric receptor, which consists of IL-6R and ubiquitously expressed glycoprotein 13 (gp13), the former of which lacks a tyrosine/kinase structural domain and binds IL-6 with low affinity. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Reference:

1. Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 2007 May;11(5):613-24. doi: 10.1517/14728222.11.5.613. PMID: 17465721.

Description

Synonym IL6, Interleukin-6, BSF2, HSF, IFNB2.
Gene ID 3569
Accession # P05231-1
Molecular Characterization Val 30 - Met 212
M.Wt 20.8 kDa
Source 293T cells
Bio Activity Determined by the dose-dependent stimulation of murine CTLL-2 cells:
ED50: < 0.1 ng/mL
Specific activity: > 1x107units/mg.

Quality Control

Quality Control & MSDS

View current batch:
    Purity ≥ 95%, by SDS-PAGE and HPLC.
    Endotoxin Level: < 0.1 ng/μg
  • Datasheet
 

Components and Storage

Formulation The protein is dissolved in PBS buffer.
Storage

This product is stable after storage at:

4°C for 1 week;

-20°C for 3 months.

Please avoid repeated freeze-thaw cycles.