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Pyrintegrin

Catalog No.
C3882
enhances the survival of hESC
Grouped product items
SizePriceStock Qty
1mg
$88.00
Ship with 5-10 days
5mg
$243.00
Ship with 5-10 days
10mg
$354.00
Ship with 5-10 days

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Email: [email protected]

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Background

Pyrintegrin, a 2,4-disubstituted pyrimidine, is a novel small-molecule inhibitor of BMP signaling which previously found to promote human embryonic stem cells survival [1].

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of secreted signaling molecules with important roles in many biological contexts. BMPs could bind to specificserine/threonine kinase receptors and transduce the signal to the nucleus through Smad proteins [2].

In vitro: Pyrintegrin induced differentiation of hADSCs into adipogenic‐like cells in vitro. Pyrintegrin drug treatment can accelerate adipocyte differentiation and augment lipid accumulation, adiponectin and fatty acid secretion in adipogenic medium differentiated human adipose derived stem cells [1]. Pyrimidine (2 μM) enhanced the survival of hESC more than 30-fold after trypsin-mediated dissociation. Pyrimidine increased integrin-dependent attachment of hESC to extracellular matrices without significantly impacting cell proliferation. Pyrintegrin increased the binding of the activated β1 integrin-specific antibody HUTS-21 and enhanced the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK [3].

In vivo: Pyrintegrin promoted proliferation and differentiation of adipose precursor cells depending on their microenvironment. Pyrintegrin increased the number of preadipocytes and the rate of adipocyte differentiation, resulting in enhanced de novo adipogenesis [1].

References:
[1] Shah B S.  Pyrintegrin Induced Adipogenesis: Biology[D]. Columbia University, 2012.
[2] von Bubnoff A, Cho K W Y.  Intracellular BMP signaling regulation in vertebrates: pathway or network[J]. Developmental biology, 2001, 239(1): 1-14.
[3] Xu Y, Zhu X, Hahm H S, et al.  Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules[J]. Proceedings of the National Academy of Sciences, 2010, 107(18): 8129-8134.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt451.5
Cas No.1228445-38-2
FormulaC23H25N5O3S
Solubility≤1mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
Chemical NameN-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-benzenesulfonamide
SDFDownload SDF
Canonical SMILESOC1=CC2=C(C=C1)N(C3=CC=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=N3)CCC2
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Pyrintegrin