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Posaconazole hydrate

Catalog No.
B1225
C14ɑ demethylase inhibitor
Grouped product items
SizePriceStock Qty
5mg
$119.00
Ship with 10-15 days
10mg
$180.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.

Chemical Properties

StorageStore at -20°C
M.Wt718.79
Cas No.1198769-38-8
FormulaC37H44F2N8O5
SolubilitySoluble in DMSO
Chemical Name4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one hydrate
SDFDownload SDF
Canonical SMILESCC[[email protected]@](N(N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[[email protected]@](CO5)([H])C[[email protected]@]5(C6=C(F)C=C(F)C=C6)CN7C=NC=N7)C=C4)CC3)C=C2)C1=O)([H])[[email protected]](O)([H])C.O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Posaconazole hydrate