Paxilline
Catalog No.
B6920
high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels blocker
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Paxilline (CAS: 57186-25-1) is a fungal-derived indole diterpene recognized primarily for its potent, reversible blockade of large-conductance calcium-activated potassium (BKCa or KCa1.1) channels. By interacting with these channels, paxilline increases the binding affinity of charybdotoxin, a neurotoxic peptide, to BKCa ion channels. Additionally, it inhibits sarco/endoplasmic reticulum Ca2? ATPase (SERCA) activity at micromolar concentrations (IC50 range: 5–50 μM). Given these bioactivities, paxilline serves as a valuable pharmacological tool for investigating calcium-dependent potassium channel physiology and calcium homeostasis in cellular research.
| Physical Appearance | A crystalline solid |
| Storage | Desiccate at -20°C |
| M.Wt | 435.56 |
| Cas No. | 57186-25-1 |
| Formula | C27H33NO4 |
| Solubility | Soluble in DMSO |
| Chemical Name | (2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
| SDF | Download SDF |
| Canonical SMILES | O[C@]1(C2=C3)[C@@](CC[C@@H]2O[C@H](C(C)(C)O)C3=O)(C)[C@](C(NC4=CC=CC=C54)=C5C6)(C)[C@@H]6CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
