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Oxy-16

Catalog No.
C5136
antagonist of hedgehog activity
Grouped product items
SizePriceStock Qty
1mg
$130.00
Ship with 5-10 days
5mg
$582.00
Ship with 5-10 days
10mg
$1,035.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Oxy-16 is an antagonist of hedgehog activity.

Naturally occurring oxysterols that are products of cholesterol oxidation can stimulate the hedgehog (Hh) signaling pathway related to cardiovascular disease and bone formation. Activation of Hh signaling modulates inflammatory responses to additional atherogenic factors including lesion-producing macrophages and enable osteoblast differentiation, which is dependent on the target cell.

In vitro: Oxysterols have been shown to be associated with immunosuppression, apoptosis, atherosclerosis, inflammation, and cholesterol turnover. Other studies aslo indicated that oxysterols were Hedgehog (Hh) signaling pathway activators and had potent osteoinductive properties. Oxy-16, an oxysterol, was identified as a cell permeable oxygenated derivative of cholesterol that might be the end product or intermediate of the cholesterol excretion pathways. Oxy-16 is currently used as a transport form for cholesterol across the blood brain barrier and membranes. The osteogenic differentiation caused by Oxy-16 was cinsidered to be mediated via a Wnt signaling-related, Dkk-1-inhibitable mechanism [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Amantea, C. M.,Kim, W.K.,Meliton, V., et al. Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling. Journal of Cellular Biochemistry 105(2), 424-436 (2008).

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt418.7
Cas No.596-94-1
FormulaC27H46O3
Synonyms20(R),22(R)-dihydroxy Cholesterol
Solubility≤10mg/ml in ethanol;1.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
Chemical Namecholest-5-ene-3b,20,22R-triol
SDFDownload SDF
Canonical SMILESO[[email protected]](C1)CC[[email protected]@]2(C)C1=CC[[email protected]]3([H])C2CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]]4([H])[[email protected]@](C)(O)[[email protected]](O)CCC(C)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Oxy-16