Toggle Nav
  • Menu
  • Setting


Catalog No.
Amine-reactive biotinylation reagent, mid-length
Grouped product items
SizePriceStock Qty
In stock
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors


NHS-SS-11-biotin  is a long-chain cleavable amine-reactive biotinylation reagent that has a spacer arm of 24.3 A in length due to the existence of a cross-bridge within its chemical structure. The long spacer arm creates an increased length between a covalently modified molecule and the bicyclic biotin rings that greatly enhances the ability of the molecule to bind to avidin or streptavidin probes. The NHS ester group of NHS-SS-11-biotin reacts with the amine groups of proteins and other molecule forming an amide bond and releasing of sulfo-NHS. NHS-SS-11-Biotin is a water-insoluble molecule that requires the dissolution of organic solvents prior to be added to aqueous reactions.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.142439-92-7
Solubilityinsoluble in H2O; insoluble in EtOH; ≥16.83 mg/mL in DMSO
Chemical Name2,5-dioxopyrrolidin-1-yl 3-((3-oxo-3-((2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)amino)propyl)disulfanyl)propanoate
SDFDownload SDF
Canonical SMILESO=C1N[[email protected]]2([H])[[email protected]]([[email protected]](CCCCC(NCCNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)=O)SC2)([H])N1
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control