NHS-SS-11-Biotin
Catalog No.
A8016
Amine-reactive biotinylation reagent, mid-length
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NHS-SS-11-Biotin (CAS: 142439-92-7) is an amine-reactive biotinylation reagent commonly used in biochemical research. Structurally, it possesses an N-hydroxysuccinimide (NHS) ester group that covalently reacts with primary amines of target proteins or biomolecules, forming stable amide bonds and releasing sulfo-NHS. This reagent features a cleavable disulfide linker and an extended spacer arm of approximately 24.3 ?, enhancing probe accessibility to avidin or streptavidin conjugates. It is utilized extensively for reversible biotinylation, affinity purification, or labeling studies in proteomics and cell biology applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 575.72 |
| Cas No. | 142439-92-7 |
| Formula | C22H33N5O7S3 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥16.83 mg/mL in DMSO |
| Chemical Name | 2,5-dioxopyrrolidin-1-yl 3-((3-oxo-3-((2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)amino)propyl)disulfanyl)propanoate |
| SDF | Download SDF |
| Canonical SMILES | O=C1N[C@]2([H])[C@]([C@H](CCCCC(NCCNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)=O)SC2)([H])N1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
