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Neoruscogenin

Catalog No.
C3841
nuclear receptor RORα agonist
Grouped product items
SizePriceStock Qty
1mg
$137.00
Ship with 5-10 days
5mg
$543.00
Ship with 5-10 days
10mg
$950.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα [1]. Neoruscogenin is a natural sapogenin extracted from Butcher’s broom (Rusci rhizoma, Ruscus aculeatus, Ruscaceae) [2].

RAR-related orphan receptor alpha (RORα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. Genetic studies have revealed that RORα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].

In vitro: In confluent human microvascular endothelial cells (HMEC-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μM (71.8%). The EC50 of neoruscogenin against the nuclear receptor RORα was 110 nM [1].

In vivo: In mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several RORα-inducible genes in the liver [1].

References:
[1] Helleboid S, Haug C, Lamottke K, et al.  The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1)[J]. Journal of biomolecular screening, 2013: 1087057113497095.
[2] Barbi M, Willer E A, Rothenhfer M, et al.  Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[J]. Phytochemistry, 2013, 90: 106-113.
[3] Giguère V.  Orphan nuclear receptors: from gene to function 1[J]. Endocrine reviews, 1999, 20(5): 689-725.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt428.6
Cas No.17676-33-4
FormulaC27H40O4
Synonyms25(27)-Dehydroruscogenin
Solubility≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Namespirosta-5,25(27)-diene-1β,3β-diol
SDFDownload SDF
Canonical SMILESC=C(CO1)CC[[email protected]@]21O[[email protected]@]3([H])C[[email protected]@]4([H])[[email protected]]5([H])CC=C6C[[email protected]@H](O)C[[email protected]@H](O)[[email protected]]6(C)[[email protected]@]5([H])CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H]2C
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Neoruscogenin