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N-Oxalylglycine

Catalog No.
C3095
cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E.
Grouped product items
SizePriceStock Qty
10mg
$55.00
In stock
50mg
$77.00
In stock
100mg
$110.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

IC50: 250 μM: inhibits α-ketoglutarate-dependent enzyme jumonji domain-containing protein 2 (JMJD2) A.

IC50: 500 μM: blocks α-ketoglutarate-dependent enzyme JMJD2C.

IC50: 24 μM: dampens α-ketoglutarate-dependent enzyme JMJD2E.

IC50: 2.1 μM: suppresses the prolyl hydroxylase domain-containing proteins PHD1.

IC50: 5.6 μM: depresses the prolyl hydroxylase domain-containing proteins PHD2.

N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.

In vitro: NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases [1].

In vivo: Up to now, in vivo study of NOG is still in the development stage.

Reference:
[1].  Al-Qahtani, K., Jabeen, B., Sekirnik, R., Riaz, N., Claridge, T., Schofield, C., & McCullagh, J. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 2015; 117: 456-461.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt147.1
Cas No.5262-39-5
FormulaC4H5NO5
SynonymsNOG
Solubilityinsoluble in EtOH; ≥3.82 mg/mL in DMSO with ultrasonic; ≥9.55 mg/mL in H2O
Chemical NameN-(carboxycarbonyl)-glycine
SDFDownload SDF
Canonical SMILESOC(C(NCC(O)=O)=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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