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N-Oxalylglycine

Catalog No.
C3095
cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E.
Grouped product items
SizePriceStock Qty
10mg
$57.00
In stock
50mg
$117.00
In stock
100mg
$165.00
In stock

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Background

IC50: 250 μM: inhibits α-ketoglutarate-dependent enzyme jumonji domain-containing protein 2 (JMJD2) A.

IC50: 500 μM: blocks α-ketoglutarate-dependent enzyme JMJD2C.

IC50: 24 μM: dampens α-ketoglutarate-dependent enzyme JMJD2E.

IC50: 2.1 μM: suppresses the prolyl hydroxylase domain-containing proteins PHD1.

IC50: 5.6 μM: depresses the prolyl hydroxylase domain-containing proteins PHD2.

N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.

In vitro: NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases [1].

In vivo: Up to now, in vivo study of NOG is still in the development stage.

Reference:
[1].  Al-Qahtani, K., Jabeen, B., Sekirnik, R., Riaz, N., Claridge, T., Schofield, C., & McCullagh, J. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 2015; 117: 456-461.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt147.1
Cas No.5262-39-5
FormulaC4H5NO5
SynonymsNOG
Solubility≤10mg/ml in ethanol;10mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical NameN-(carboxycarbonyl)-glycine
SDFDownload SDF
Canonical SMILESOC(C(NCC(O)=O)=O)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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