In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Muscone is a potent anti-inflammatory agent, which has been implicated in reducing proinflammatory cytokines and end-plate degeneration . Muscone is a territorial releaser pheromone in Moschus moschiferus. Muscone is not produced by humans. Muscone is animal pheromone with no effects on humans comparable to those of androstadienone . (±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer .
In vitro: Muscone reversed IL-1β-induced upregulation of IL-1β, tumor necrosis factor α, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2α1 and aggrecan. In end-plate cartilage cultures, pretreatment with muscone (6.25, 12.5, 25 μmol/L) inhibited the IL-1β-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinase in a dose-dependent manner .
In vivo: In a rat model with induced intervertebral disc degeneration, muscone inhibited the expression of prostaglandin E2, 6-keto-prostaglandin F1α, IL-1β, and tumor necrosis factor α and recovered the structural distortion of the degenerative disc .
 Liang Q Q, Zhang M, Zhou Q, et al. Muscone protects vertebral end-plate degeneration by antiinflammatory property[J]. Clinical Orthopaedics and Related Research, 2010, 468(6): 1600-1610.
 Jacob S, Garcia S, Hayreh D, et al. Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone[J]. Hormones and behavior, 2002, 42(3): 274-283.
 Fujimoto, S. ,Yoshikawa, K.,Itoh, M., et al. Synthesis of (R)- and (S)- muscone. Bioscience, Biotechnology, and Biochemistry 66(6), 1389-1392 (2002).
|Physical Appearance||A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.|
|Storage||Store at -20°C|
|Solubility||≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|