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Muscone

Catalog No.
C3973
anti-inflammatory effects
Grouped product items
SizePriceStock Qty
100mg (solution)
$78.00
Ship with 5-10 days
500mg (solution)
$316.00
Ship with 5-10 days
1g (solution)
$533.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Muscone is a potent anti-inflammatory agent, which has been implicated in reducing proinflammatory cytokines and end-plate degeneration [1]. Muscone is a territorial releaser pheromone in Moschus moschiferus. Muscone is not produced by humans. Muscone is animal pheromone with no effects on humans comparable to those of androstadienone [2]. (±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer [3].

In vitro: Muscone reversed IL-1β-induced upregulation of IL-1β, tumor necrosis factor α, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2α1 and aggrecan. In end-plate cartilage cultures, pretreatment with muscone (6.25, 12.5, 25 μmol/L) inhibited the IL-1β-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinase in a dose-dependent manner [1].

In vivo: In a rat model with induced intervertebral disc degeneration, muscone inhibited the expression of prostaglandin E2, 6-keto-prostaglandin F1α, IL-1β, and tumor necrosis factor α and recovered the structural distortion of the degenerative disc [1].

References:
[1] Liang Q Q, Zhang M, Zhou Q, et al.  Muscone protects vertebral end-plate degeneration by antiinflammatory property[J]. Clinical Orthopaedics and Related Research, 2010, 468(6): 1600-1610.
[2] Jacob S, Garcia S, Hayreh D, et al.  Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone[J]. Hormones and behavior, 2002, 42(3): 274-283.
[3] Fujimoto, S. ,Yoshikawa, K.,Itoh, M., et al. Synthesis of (R)- and (S)- muscone. Bioscience, Biotechnology, and Biochemistry 66(6), 1389-1392 (2002).

Chemical Properties

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt238.4
Cas No.541-91-3
FormulaC16H30O
Synonyms3-Methylcyclopentadecanone
Solubility≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name3-methyl-cyclopentadecanone
SDFDownload SDF
Canonical SMILESO=C1CCCCCCCCCCCCC(C)C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Muscone