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MLS-573151

Catalog No.
C4738
Cdc42 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$131.00
Ship with 5-10 days
10mg
$229.00
Ship with 5-10 days
25mg
$485.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

MLS-573151 is a specific and cell permeable inhibitor of Cdc42 [1].

Cdc42 is a small GTPase of the Rho family involved in regulating signaling pathways that control diverse cellular functions such as cell morphology, cell migration, cell cycle progression and endocytosis [2].

In vitro: MLS-573151 was a specific, cell permeable inhibitor of Cdc42 with an IC50 of 2 μM [1]. MLS-573151 showed no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. MLS-573151 functioned by blocking the binding of GTP to Cdc42 [1]. In marrow-derived mesenchymal stem cells, MLS-573151 showed no effect on cell migration [3].

References:
[1] Surviladze Z, Waller A, Wu Y, et al.  Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay[J]. Journal of biomolecular screening, 2010, 15(1): 10-20.
[2] Qadir M I, Parveen A, Ali M.  Cdc42: Role in Cancer Management[J]. Chemical biology & drug design, 2015, 86(4): 432-439.
[3] Wang L, Yang L, Tian L, et al.  Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury[J]. Journal of cellular physiology, 2017, 232(1): 110-121.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt377.5
Cas No.10179-57-4
FormulaC21H19N3O2S
Solubility≤20mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
SDFDownload SDF
Canonical SMILESNS(C(C=C1)=CC=C1N2C(C3=CC=CC=C3)CC(C4=CC=CC=C4)=N2)(=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

MLS-573151