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Mefloquine hydrochloride

Catalog No.
A3593
Quinoline methanol antimalarial agent,
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$60.00
In stock
100mg
$55.00
In stock
1g
$285.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

Description: IC50 Value: 1 microM ( for K+ channel) [1] Mefloquine is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. MQ can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to kill cancer cells [2]. in vitro: Mefloquine inhibitedKvLQT1/minK channel currents with an IC50 value of approximately 1 microM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones. HERG channel currents were about 6-fold less sensitive to block by mefloquine (IC50 = 5.6 microM). Block of HERG displayed a positive voltage dependence with maximal inhibition obtained at more depolarized potentials [1]. MQ has a highly selective cytotoxicity that inhibits PCa cell growth. MQ-mediated ROS simultaneously downregulated Akt phosphorylation and activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and adenosine monophosphate-activated protein kinase (AMPK) signaling in PC3 cells [2]. in vivo: Pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9-11 post coitum (pc). The dams were euthanized on day 12 pc and gestational and embryos histological parameters were evaluated [3]. Clinical trial: Activity of Mefloquine Against Urinary Schistosomiasis . Phase 2

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt414.77
Cas No.51773-92-3
FormulaC17H17ClF6N2O
SynonymsMefloquin hydrochloride
Solubilityinsoluble in H2O; ≥20.74 mg/mL in DMSO; ≥33.67 mg/mL in EtOH
Chemical Name(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol;hydrochloride
SDFDownload SDF
Canonical SMILESC1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control