In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MC 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and DNA-synthesis of cells possessing the receptor for 1,25(OH)2D3. MC 1046 is the metabolite of calcipotrioI (MC 903), which is a novel analogue of the physiologically active metabolite of vitamin D3.
In vitro: The biological effects on the U937 cells of the two major metabolites of MC 903 (MC 1046 and MC 1080) were investigated. Results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound .
In vivo: MC 903 is a novel analogue of the physiologically active metabolite of 1,25(OH)2D3. Unlike the similar effects on cell proliferation and cell differentiation in vitro, MC 903 has 100-200 times less effect on calcium metabolism in vivo. Moreover, rat study indicats that the effect of MC 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes MC 903 suitable for topical treatment of psoriasis .
Clinical trial: No clinical data are available for MC 1046 and its analogues.
 Kissmeyer AM, Binderup L. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991;41(11):1601-6.
|Storage||Store at -20°C|
|Synonyms||Impurity A of Calcipotriol|
|Solubility||Soluble in DMSO|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
|Description||MC 1046 is impurity of Calcipotriol.|