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matrix protein (3-15) [Zaire ebolavirus]

Catalog No.
A1080
Viral envelope associated protein peptide
Grouped product items
SizePriceStock Qty
1mg
$50.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$350.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Matrix protein (3-15) is a peptide of the structure proteins linking the viral envelope with theZaireebolavirus core.

Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of severe hemorrhagic fevers in human and non-human primates with high case fatality rates.

A role for matrix proteins in the regulation of viral genome replication and transcription has been shown for a number of negative strand RNA viruses. The recent study has shown that both matrix proteins of EBOV, VP40 and VP24, are able to inhibit both viral genome replication and transcription.

A1080_1

Figure 1: Ribbon image of matrix protein VP40 of theZaire ebolavirus

Ref:

1. Hoenen T, Jung S, Herwig A, Groseth A, Becker S (2010) Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription. Virology 403: 56–66.

2. Dessen A, Viktor V, Dolnik O, Klenk H, Weissenhorn W. Crystal structure of the matrix protein VP 40 from Ebola virus. The EMBO Journal (2010) 19, 4228-4236.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1515.77
FormulaC69H110N16O20S
SynonymsH2N-Arg-Val-Ile-Leu-Pro-Thr-Ala-Pro-Pro-Glu-Tyr-Met-Glu-OH
Solubility≥151.6mg/mL in DMSO
SDFDownload SDF
Canonical SMILESNC(CCCNC(N)=N)C(NC(C(C)C)C(NC(C(C)CC)C(NC(CC(C)C)C(N(CCC1)C1C(NC(C(C)O)C(NC(C)C(N2CCCC2C(N3CCCC3C(NC(C(NC(CC4=CC=C(O)C=C4)C(NC(CCSC)C(NC(CCC(O)=O)C(O)=O)=O)=O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

matrix protein (3-15) [Zaire ebolavirus]