lsoursodeoxycholic acid

3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid and belongs to the steroid compounds. 3β -ursodeoxycholic acid shows good tolerance and intestinal absorption characteristics when administered orally. After entering the body, it can be isomerized by enzyme systems in the intestinal mucosa and liver (such as hydroxysteroid dehydrogenase) and converted into Ursodeoxycholic acid (UDCA) - a drug clinically used to treat cholestatic liver disease. This metabolic transformation makes it a potential prodrug form of UDCA, which may function by enhancing bioavailability or optimizing pharmacokinetic properties. As a member of the bile acid family, it may also be involved in regulating the composition of the bile acid pool, influencing cholesterol solubility and lipid metabolism in the liver and gallbladder. Current research focuses on its medicinal potential as a precursor of UDCA and the regulatory mechanism of isomerization in the hepatoenteric circulation, providing structural optimization ideas for the development of new bile acid drugs.