LiCl
Catalog No.
B6083
used to precipitate RNA
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Lithium chloride (LiCl, CAS 7447-41-8) is an ionic compound widely utilized as a selective precipitant for RNA isolation in molecular biology research. Due to its physicochemical properties, LiCl preferentially precipitates RNA while generally not interacting appreciably with DNA, proteins, or polysaccharides. Researchers commonly employ LiCl precipitation to purify intact, translationally active RNA from complex samples, including those containing translation inhibitors or synthesized cDNA. Additionally, LiCl-mediated RNA precipitation following guanidine thiocyanate homogenization enables rapid, scalable purification of large mRNA species up to 10 kb, benefiting workflows by avoiding ultracentrifugation steps.
- 1. Maowen Sun, Cong Yuan, et al. "GSK3 maintains NSP12 stability to promote bat-origin swine acute diarrhea syndrome coronavirus infection." J Virol. 2026 Sep 30:e0068326. PMID: 42813780
- 2. Ge Z, Yang Y, et al. "Overexpression of the hyperplasia suppressor gene inactivates airway fibroblasts obtained from a rat model of chronic obstructive pulmonary disease by inhibiting the Wnt signaling pathway." Mol Med Rep. 2019 Sep;20(3):2754-2762 PMID: 31322244
- 3. Weihua Xu, Jin Li, et al. "MicroRNA-186-5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non-traumatic osteonecrosis." Molecular Medicine Reports. September 26, 2019
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 42.39 |
| Cas No. | 7447-41-8 |
| Formula | ClLi |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥4.2 mg/mL in H2O |
| Chemical Name | lithium chloride |
| Canonical SMILES | [Li+].[Cl-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
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