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LEP (116-130) (mouse)An antiobesity hormone

LEP (116-130) (mouse)

Catalog No. A1024
Size Price Stock Qty
1mg $80.00 In stock
5mg $240.00 In stock
10mg $400.00 In stock
25mg $560.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

LEP (116-130) (mouse)

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Chemical Properties

Cas No. 258276-95-8 SDF Download SDF
Synonyms Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser
Chemical Name LEP (116-130) (mouse)
Formula C64H109N19O24S M.Wt 1560.73
Solubility Soluble to 1 mg/ml in sterile water Storage Desiccate at -20°C
General tips N/A
Shipping Condition N/A


Leptin (116-130), amide, mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. Since the discovery of leptin, the breadth of biological actions has dramatically expanded and served to broaden the initial perspective, where this protein was viewed solely as an antiobesity hormone. Important biological activities have been discovered in peripheral tissues that demonstrate the pleiotropic effects of this molecule in such areas as hematopoiesis, angiogenesis, blood pressure, bone mass, lymphoid organ homeostasis, and T lymphocyte function. Recent data indicate that leptin(116-130), an active fragment of the native molecule, exerts effects similar to those of the native peptide on body weight and food intake.



Figure1  Formula of Leptin (116-130)



Figure2  Signal transduction pathways of leptin


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