In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Kainic acid is a selective agonist of kainate receptor .
Kainate receptor is an ionotropic receptor that responds to glutamate. Presynaptic kainate receptor modulates GABA release and is involved in inhibitory neurotransmission. Postsynaptic kainate receptor is involved in excitatory neurotransmission.
In aged rats, kainic acid significantly reduced the latency to full clonic-tonic seizures and increased the amount of seizures rats. Also, kainic acid significantly increased the release of norepinephrine (NE), ASP and GLU in aged rats with clonic-tonic seizures . In neonatal rats, intrahippocampal injection of kainic acid (1 μg) significantly induced pyramidal cell death . In adult rats, kainic acid significantly increased the mRNA levels of neurotrophin-4/5 (NT-4/5) in the dorsal horn and in the spinal cord white matter, and increased the mRNA level of brain-derived neurotrophic factor (BDNF) in the ventral horn. While kainic acid didn’t affect neurotrophin-3 (NT-3). These results suggested that NT-4/5 and BDNF participated in the response of the spinal cord to excitotoxic stimuli induced by kainic acid .
. Dawson R Jr, Wallace DR. Kainic acid-induced seizures in aged rats: neurochemical correlates. Brain Res Bull, 1992, 29(3-4): 459-468.
. Cook TM, Crutcher KA. Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience, 1986, 18(1): 79-92.
. Scarisbrick IA, Isackson PJ, Windebank AJ. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid. J Neurosci, 1999, 19(18): 7757-7769.
|Physical Appearance||A solid|
|Storage||Store at RT|
|Solubility||≥11.05mg/mL in H2O with gentle warming|
|Chemical Name||(2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid|
|Canonical SMILES||OC([[email protected]]1NC[[email protected]](C(C)=C)[[email protected]@H]1CC(O)=O)=O|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|