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JNJ-1661010

Catalog No.
A4361
FAAH inhibitor,potent and selective
Grouped product items
SizePriceStock Qty
10mg
$253.00
Ship with 5-10 days
50mg
$1,043.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

JNJ-1661010, a piperazinyl phenyl urea with its structure distinct from alkylcarbamic acid esters and α–ketoheterocyclic compounds, is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH) that covalently binds to the active site of FAAH through cleavage of the urea functionality generating aniline and a FAAH-poperazinyl carbamate. The inhibition of JNJ-1661010 against FAAH is reversible through the hydrolysis of the carbamate leading to the release of the piperazinyl fragment and the restoration of enzymatic functionality of FAAH. According to results of previous studies, JNJ-1661010 displays its inhibition against recombinant FAAH with values of 50% inhibition concentration IC50 of 10 nM and 12 nM in rat and human respectively.

Reference

Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL, Keith JM, Wu J, Breitenbucher JG, Chaplan SR, Webb M. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009;108(1):316-329.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt365.45
Cas No.681136-29-8
FormulaC19H19N5OS
SynonymsJNJ 1661010,JNJ1661010
SolubilitySoluble in DMSO
Chemical NameN-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
SDFDownload SDF
Canonical SMILESC1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Biological Activity

Description JNJ-1661010 is a selective inhibitor of FAAH with IC50 values of 33 nM and 34 nM in human and rat, respectively.
Targets FAAH FAAH        
IC50 33 nM (human) 34 nM (rat)        

Quality Control

Quality Control & MSDS

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Chemical structure

JNJ-1661010