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Interleukin II (60-70)

Catalog No.
A1030
Cytokine,regulating WBC
Grouped product items
SizePriceStock Qty
1mg
$50.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$350.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Interleukin II (60-70), (C68H104N14O14S), is a peptide with the sequence NH2- LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW= 1373.7. Interleukin 2 (IL-2) is a type of cytokine signaling molecule in the immune system, and it regulates the activities of the white blood cells (leukocytes, often lymphocytes) responsible for immunity. IL-2, a soluble hormone-like mediator of the immune system, was the first interleukin molecule to be identified and characterized. IL-2 is necessary for the growth, proliferation, and differentiation of T cells to become 'effector' T cells. IL-2 is normally produced by T cells during an immune response. It is necessary for the development of T cell immunologic memory, which depends upon the expansion of the number and function of antigen-selected T cell clones.IL-2 is also necessary for the maturation of a subset of T cells, termed regulatory T cells, during T cell development in the thymus.

A1030_1 

Figure1  Formula of Interleukin II (60-70)

A1030_2 

Figure2  Summary of effects of Interleukin II 

Ref:

1. Cantrell DA, Smith KA (June 1984). "The interleukin-2 T-cell system: a new cell growth model". Science 224 (4655): 1312–6.

2. Smith KA (May 1988). "Interleukin-2: inception, impact, and implications". Science 240 (4856): 1169–76.

3. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (August 1995). "Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases". J. Immunol. 155 (3): 1151–64.

4. ThorntonAM, Shevach EM (July 1998). "CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production". J. Exp. Med. 188 (2): 287–96.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1373.7
FormulaC68H104N14O14S1
SynonymsH2N-Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala-OH
Solubility≥137.3mg/mL in DMSO
SDFDownload SDF
Canonical SMILESN[[email protected]@H](CC(C)C)C(N[[email protected]]([[email protected]@H](C)O)C(N[[email protected]](CC1=CC=CC=C1)C(N[[email protected]](CCCCN)C(N[[email protected]](CC2=CC=CC=C2)C(N[[email protected]](CC3=CC=C(O)C=C3)C(N[[email protected]](CCSC)C(N4CCC[[email protected]@H]4C(N[[email protected]@H](CCCCN)C(N[[email protected]@H](CCCCN)C(N[[email protected]@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Interleukin II (60-70)