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Catalog No.
cell impermeable tyrosine kinase inhibitor
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Ship with 5-10 days
Ship with 5-10 days
Ship with 5-10 days

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HNMPA is a tyrosine kinase inhibitor that inhibited both the receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity [1].

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for growth factors, cytokines, and hormones. The insulin receptor is one of a number of growth factor receptors with intrinsic tyrosine kinase activity that can be activated upon ligands binding [1].

HNMPA (Hydroxy-2-naphthalenylmethyl Phosphonic Acid) is a tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation. HNMPA does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibited tyrosine kinase activity of autophosphorylated insulin receptor towards poly (Glu4, Tyr) or insulin receptor-(1155-1165) peptide by 82% and 81%, respectively. HNMPA also inhibited autophosphorylation of insulin receptors by 13% + 4.6% in the presence of insulin. HNMPA not only inhibited insulin receptor tyrosine phosphorylation but also effectively decreased insulin receptor serine phosphorylation [1]. In β-cells exposed to high glucose, HNMPA was able to further increase the exe-4-induced insulin secretion [2].

[1].  Baltensperger K, Lewis RE, Woon CW, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9.
[2].  Moon MJ, Kim HY, Park S, et al. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Mol Cells. 2011 Oct;32(4):389-95.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
Cas No.132541-52-7
SynonymsHydroxy-2-naphthalenylmethyl Phosphonic Acid
Solubility≤20mg/ml in ethanol;1mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical NameP-(hydroxy-2-naphthalenylmethyl)-phosphonic acid
SDFDownload SDF
Canonical SMILESOC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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Chemical structure