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Hinokitiol

Catalog No.
B8206
A potent apoptosis inducer and iron chelator
Grouped product items
SizePriceStock Qty
50mg
$55.00
In stock
100mg
$99.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Hinokitiol, a natural bioactive compound of aromatic tropolone, is a potent apoptosis inducer and iron chelator. Hinokitiol reduces the expression of nuclear factor erythroid 2-related 2 (Nrf2) which is an emerging regulator of antioxidant response, maintaining redox homeostasis in the cells. Interfering Nrf2 expression has been shown to disrupt the self-renewal of glioma stem cells and make tumors sensitive to chemoradiotherapy. In addition, hinokitiol may also induce DNA demethylation by reducing the mRNA and protein expression of DNA methyltransferase 1 (DNMT1) and ubiquitin-like plant homeodomain and RING finger domain 1 (UHRF1), to achieve its anti-tumor activities in cancers like colon cancer. 

References:

1. Ouyang WC, Liao YW, Chen PN, et al. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemotherapy and Pharmacology, 2017, 80(2): 411-419.

2. Seo JS, Choi YH, Moon JW, et al. Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biology, 2017, 18(1): 14.

3. Ido Y, Muto N, Inada A, et al. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Proliferation, 1999, 32(1): 63-73.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt164.20
Cas No.499-44-5
FormulaC10H12O2
Solubilityinsoluble in H2O; ≥118.6 mg/mL in EtOH; ≥16.4 mg/mL in DMSO
Chemical Name2-hydroxy-4-isopropylcyclohepta-2,4,6-trienone
SDFDownload SDF
Canonical SMILESOC1=CC(C(C)C)=CC=CC1=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Glioma stem cells derived from U87MG and T98G glioma cell lines

Reaction Conditions

24 h incubation

Applications

Hinokitiol dose-dependently decreased cell viability, with IC50 values being 316.5 ± 35.5 and 152.5 ± 25.3 µM for U87MG and T98G glioma cell lines, respectively. Furthermore, hinokitiol effectively inhibited the CD133 positivity and aldehyde dehydrogenase 1 (ALDH1) activity, and repressed the self-renewal, migration, invasion, and colony formation abilities of glioma stem cells.

Note

The technical data provided above is for reference only.

References:

1. Ouyang WC, Liao YW, Chen PN, et al. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemotherapy and Pharmacology, 2017, 80(2): 411-419.

2. Seo JS, Choi YH, Moon JW, et al. Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biology, 2017, 18(1): 14.

3. Ido Y, Muto N, Inada A, et al. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Proliferation, 1999, 32(1): 63-73.

Quality Control

Chemical structure

Hinokitiol