Toggle Nav
  • Menu
  • Setting

Hexadecyl Methyl Glycerol

Catalog No.
protein kinase C activity inhibitor
Grouped product items
SizePriceStock Qty
50mg (solution)
Ship with 5-10 days
100mg (solution)
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors


Hexadecyl Methyl Glycerol, also known as AMG-C16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase C with IC50 value of about 80 μM [1].

Protein kinase C is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (PMA), a substance that activates both the respiratory burst and protein kinase C. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+) [1].

Hexadecyl Methyl Glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. Hexadecyl Methyl Glycerol inhibited the activation of purified protein kinase C by diacylglycerol in the presence of phosphatidylserine. In neutrophilic granulocytes, Hexadecyl Methyl Glycerol inhibited the respiratory burst induced by PDBu in a dose-dependent way. In neutrophils, Hexadecyl Methyl Glycerol inhibited the phosphorylation of purified 47-kDa protein, an important substrate of protein kinase C [1].

[1].  Kramer IM1, van der Bend RL, Tool AT, et al. 1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils. J Biol Chem. 1989 Apr 5;264(10):5876-84.

Chemical Properties

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
Cas No.96960-92-8
Solubility≤8.3mg/ml in DMSO;8.3mg/ml in dimethyl formamide
Chemical Name1-O-hexadecyl-2-O-methyl-sn-glycerol
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Hexadecyl Methyl Glycerol