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Helioxanthin derivative 5-4-2

Catalog No.
B4700
HBV/HSV-1/HSV-2 virus inhibitor
Grouped product items
SizePriceStock Qty
2mg
$368.00
Ship with 10-15 days
5mg
$551.00
Ship with 10-15 days
10mg
$788.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 μM, 0.29 μM and 0.16 μM, respectively [1].

Helioxanthin derivative 5-4-2 is a lactam and has been reported to inhibit the HBV DNA and RNA and viral protein expression [2]. Helioxanthin derivative 5-4-2 has significant anti-virus activity with EC50 values of 0.08 μM, 0.29 μM and 0.16 μM for HBV(hepatitis B virus), HSV-1(herpes simplex virus type 1) and HSV-2(herpes simplex virus type 2), respectively [1]. In addition, Helioxanthin derivative 5-4-2 inhibited HBV replication by post-transcriptional down-regulation of necessary transcription factors [3]. Helioxanthin derivative 5-4-2 has also exhibited potent anti-HCV (hepatitis C virus) activity with 55% inhibition at 1.0 μM and 80%inhibition at 3.0 μM [1].

References:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2] Li Y1, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, ChengYC.Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.
[3] Stein LL1, Loomba R. Drug targets in hepatitis B virus infection. Infect Disord Drug Targets. 2009 Apr;9(2):105-16.

Chemical Properties

StorageStore at -20°C
M.Wt347.32
Cas No.203935-39-1
FormulaC20H13NO5
SolubilitySoluble in DMSO
Chemical Name10-(benzo[d][1,3]dioxol-5-yl)-9H-[1,3]dioxolo[4',5':3,4]benzo[1,2-f]isoindol-7-ol
SDFDownload SDF
Canonical SMILESOC1=NCC2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Helioxanthin derivative 5-4-2