Helioxanthin derivative 5-4-2
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 μM, 0.29 μM and 0.16 μM, respectively .
Helioxanthin derivative 5-4-2 is a lactam and has been reported to inhibit the HBV DNA and RNA and viral protein expression . Helioxanthin derivative 5-4-2 has significant anti-virus activity with EC50 values of 0.08 μM, 0.29 μM and 0.16 μM for HBV(hepatitis B virus), HSV-1(herpes simplex virus type 1) and HSV-2(herpes simplex virus type 2), respectively . In addition, Helioxanthin derivative 5-4-2 inhibited HBV replication by post-transcriptional down-regulation of necessary transcription factors . Helioxanthin derivative 5-4-2 has also exhibited potent anti-HCV (hepatitis C virus) activity with 55% inhibition at 1.0 μM and 80%inhibition at 3.0 μM .
 Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
 Li Y1, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, ChengYC.Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.
 Stein LL1, Loomba R. Drug targets in hepatitis B virus infection. Infect Disord Drug Targets. 2009 Apr;9(2):105-16.
|Storage||Store at -20°C|
|Solubility||Soluble in DMSO|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|