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Fluconazole

Catalog No.
B2094
fungal cytochrome P450 enzyme 14α-demethylase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$61.00
In stock
100mg
$55.00
In stock
1g
$121.00
In stock
5g
$165.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Fluconazole (CAS 86386-73-4) is a triazole-based antifungal compound widely employed in biomedical research to investigate fungal pathogenesis and antifungal drug resistance mechanisms. It functions by inhibiting fungal cytochrome P450 enzyme 14α-demethylase, disrupting ergosterol biosynthesis and interfering with fungal cell membrane integrity. Fluconazole demonstrates inhibitory activity in vitro against various pathogenic fungi, with reported IC50 values ranging approximately from 0.5 μg/mL to 10 μg/mL, dependent on fungal strain and culture conditions. Researchers commonly utilize fluconazole to explore antifungal susceptibility profiles, quantify drug-target interactions, and model fungal infections in vitro and in vivo.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt306.27
Cas No.86386-73-4
FormulaC13H12F2N6O
Solubilityinsoluble in H2O; ≥10.9 mg/mL in DMSO; ≥60.9 mg/mL in EtOH
Chemical Name2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
SDFDownload SDF
Canonical SMILESC1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:

Cell lines

The Candida albicans reference strain SC5314

Preparation method

The solubility of this compound in DMSO is >10.9mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10 μg/ml; dissolved in Milli-Q water

Applications

In wild-type Candida albicans SC5314 cells, fluconazole (10 μg/ml) and doxycycline (50 μg/ml) inhibited cell growth in a dose dependent way.

Animal experiment [2]:

Animal models

C. albicans-infected p47phox-/- knockout mice

Dosage form

80 mg/kg/day for 13 days; diluted in saline; intraperitoneal injection

Application

In C. albicans-infected p47phox-/- knockout mice, fluconazole significantly reduced splenic counts of C. albicans (P =0.008).

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Alessandro Fiori and Patrick Van Dijck. Potent Synergistic Effect of Doxycycline with Fluconazole against Candida albicans Is Mediated by Interference with Iron Homeostasis. Antimicrob Agents Chemother. 2012 Jul; 56(7): 3785–3796.

[2]. Justina Y. Ju, Cynthia Polhamus, Kieren A. Marr, et al. Efficacies of Fluconazole, Caspofungin, and Amphotericin B in Candida glabrata-Infected p47phox-/- Knockout Mice. Antimicrob Agents Chemother. 2002 May; 46(5): 1240–1245.

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