In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from Fusarium species of fungis, also they have been isolated from other genera, such as Verticillium and Halosarpheia . They have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic .
In vitro: Fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. Fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. Fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (ICAM-1) by activated macrophages, inhibited the production of the proinflammatory cytokines IL-1, TNFα and IL-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. Fusafungine also inhibited T-cell activation and proliferation, and the synthesis of IFN-γ by activated T cells . Exposure 8 h to Enniatins at nanomolar concentrations significantly stimulated cell proliferation. At low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. In the fluorescence-activated cell sorting analysis, Enniatins induced cell cycle arrest in the G0/G1 phase. In human cancer cells, elevated ENN concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities . Enniatin easily incorporated into the cell membrane in which it formed cation-selective pores .
 Sy-Cordero A A, Pearce C J, Oberlies N H. Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[J]. The Journal of antibiotics, 2012, 65(11): 541-549.
 German-Fattal M. Fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[J]. Clinical Drug Investigation, 2001, 21(9): 653-670.
 Dornetshuber R, Heffeter P, Kamyar M R, et al. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[J]. Chemical research in toxicology, 2007, 20(3): 465-473.
 Kamyar M, Rawnduzi P, Studenik C R, et al. Investigation of the electrophysiological properties of enniatins[J]. Archives of biochemistry and biophysics, 2004, 429(2): 215-223.
|Physical Appearance||A white powder|
|Storage||Store at -20°C|
|Formula||C33H57N3O9 (for B)|
|Solubility||Soluble in DMSO|
|Chemical Name||(3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone compound with (3S,6R,9S,12R,15S,18R)-3,9,15-tri((R)-sec-butyl)-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,|
|Canonical SMILES||O=C(O[[email protected]](C(C)C)C(N([[email protected]](C(O[[email protected]@H](C(N([[email protected]](C(O[[email protected]@H]1C(C)C)=O)C(C)C)C)=O)C(C)C)=O)C(C)C)C)=O)[[email protected]](C(C)C)N(C)C1=O.O=C(O[[email protected]](C(C)C)C(N([[email protected]](C(O[[email protected]@H](C(N([[email protected]](C(O[[email protected]@H]2C(C)C)=O)[[email protected]@H](CC)C)C)=O)C(C)C)=O)[[email protected]](C)CC)C)=O)[[email protected]]([[email protected]@H](CC)C)N(C)C2|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.|