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EDC.HCl

Catalog No.
A7021
Water soluble condensing reagent
Grouped product items
SizePriceStock Qty
10g
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

EDC.HCl (CAS 25952-53-8) is a water-soluble carbodiimide reagent commonly employed in peptide synthesis and other bioconjugation reactions. It facilitates amide bond formation by activating carboxyl groups, enabling their coupling with primary amines in aqueous media. The coupling mechanism involves initial activation of the carboxylic acid by EDC.HCl, generating an unstable intermediate that reacts readily with amines to produce amide linkages, and ultimately EDC is converted into a urea byproduct. Besides peptide synthesis, the reagent is also utilized for nucleotide synthesis, esterification, and lactonization reactions. EDC.HCl can be quantitatively monitored via spectrophotometric methods. Currently, no in vivo or clinical data are reported.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt191.7
Cas No.25952-53-8
FormulaC8H17N3·HCl
Solubility≥19.2 mg/mL in DMSO; ≥39 mg/mL in H2O; ≥39.6 mg/mL in ETOH
Chemical Name3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine;hydrochloride
SDFDownload SDF
Canonical SMILESCCN=C=NCCCN(C)C.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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