Deferasirox
Deferasirox (CAS 201530-41-8) is a small-molecule inhibitor targeting human transferrin-mediated iron uptake. It is designed to chelate iron ions, thereby reducing cellular iron availability and promoting iron mobilization from intracellular pools.
Deferasirox exerts its biological activity primarily through iron chelation and inhibition of transferrin-mediated iron uptake. In cell-based studies, Deferasirox demonstrates antiproliferative activity, with reported IC50 values in the micromolar range in various cancer cell lines, including lung cancer cells (DMS-53), neuroepithelioma cells (SK-N-MC), and oesophageal cancer cells (OE19, OE33).
Deferasirox holds research potential in the treatment of iron overload and as an antitumor agent.
References:
[1]. Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol, 2013, 83(1): 179-190.
[2]. Ford SJ, Obeidy P, Lovejoy DB, et al. Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. Br J Pharmacol, 2013, 168(6): 1316-1328.
- 1. Tingting Hou, Yuhang Guo, et al. "Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure." Environ Pollut. 2025 Aug 19:127009. PMID: 40840832
- 2. Tingting Hou, Xiaoteng Fan, et al. "Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells." Environ Pollut. 2024 May 1:348:123846. PMID: 38548160
- 3. Jiajia Sun, Yejing Shi, et al. "Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes." Microbiol Spectr. 2021 Dec 22;9(3):e0109421. PMID: 34756078
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 373.37 |
| Cas No. | 201530-41-8 |
| Formula | C21H15N3O4 |
| Solubility | insoluble in H2O; ≥37.28 mg/mL in DMSO; ≥2.94 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(c(cc1)ccc1-[n]1nc(-c(cccc2)c2O)nc1-c(cccc1)c1O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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