Toggle Nav
Close
  • Menu
  • Setting

Chymostatin

Catalog No.
C5589
chymotryptase-like serine proteases inhibitor
Grouped product items
SizePriceStock Qty
5mg
$103.00
Ship with 5-10 days
10mg
$195.00
Ship with 5-10 days
25mg
$462.00
Ship with 5-10 days
50mg
$873.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ki: 9.36 and 13.1 nM for chymotrypsin and chymase, respectively

Chymostatin is a chymotryptase-like serine proteases inhibitor.

Serine proteases are enzymes cleaving peptide bonds, in which serine plays as the nucleophilic amino acid. Serine proteases can be classfied into two broad categories: chymotrypsin-like (trypsin-like) or subtilisin-like.

In vitro: Chymostatin was found to be a potent inhibitor of human leucocyte chymotrypsin-like protease. Its affinity to the leucocyte protease was found to be much higher than its affinity to bovine pancreatic alpha-chymotrypsin. Chymsotatin also showed a weak inhibitory effect on the activity of human leucocyte elastase. In addition, the preincubation of chymostatin with 35SO2-4-labeled cartilage before the addition of the human chymotrypsin-like protease to the tissue could also inhibit 35SO2-4 release [1].

In vivo: The effect of chymostatin on C57BL/6J-dy dystrophic mice was studied. The locomotor activity of normal mice markedly increased, attaining a plateau at 8 weeks of age. Serum levels of creatine phosphokinase were much higher in dystrophic mice when compared with normal mice, and dystrophic mice also showed a reduced muscle protein content. When 3-week-old dystrophic mice received chymostatin at 1 mg/kg, the decrease in locomotor activity could be retarded, serum enzyme levels significantly decreased, and muscle protein content also obviously increased. In addition, the survival time of chymostatin-treated dystrophic mice was prolonged [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Feinstein, G. ,Malemud, C.J., and Janoff, A. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim.Biophys.Acta. 429(3), 925-932 (1976).
[2] Komatsu K, Matsui A, Satoh S.  Beneficial effect of chymostatin on dystrophic mice. Exp Neurol. 1986 Jul;93(1):110-6.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt607.7
Cas No.9076-44-2
FormulaC31H41O6N7
Solubility≤10mg/ml in DMSO
Chemical Name(2R,6R,9R,12R)-6-((R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2,12-dibenzyl-9-isobutyl-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid
SDFDownload SDF
Canonical SMILESO=C(O)[[email protected]](NC(N[[email protected]]([[email protected]]1CCN=C(N)N1)C(N[[email protected]](CC(C)C)C(N[[email protected]](CC2=CC=CC=C2)C=O)=O)=O)=O)CC3=CC=CC=C3
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Chymostatin