Cerulenin
Catalog No.
C4653
fatty acid synthase (FAS) inhibitor
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Cerulenin (CAS 17397-89-6) is a natural small molecule inhibitor targeting fatty acid synthase (FAS), an enzyme essential for fatty acid biosynthesis. In rat aortic endothelial cells exposed to palmitic acid, treatment with cerulenin reduces inflammatory marker expression (IL-1β, TNFα, VCAM-1, IL-6) and restores nitric oxide production. In vivo studies using ob/ob mouse models demonstrate cerulenin-mediated reversal of hepatic steatosis, associated with decreased expression of PPARα/γ, reduced uncoupling protein 2 (UCP2), elevated hepatic ATP levels, and lower ROS production. Cerulenin serves as a useful tool in metabolic research, particularly investigating fatty acid synthesis and related metabolic diseases.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 223.3 |
| Cas No. | 17397-89-6 |
| Formula | C12H17NO3 |
| Solubility | ≤20mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | 2R,3S-epoxy-4-oxo-7,10-dodecadienamide |
| SDF | Download SDF |
| Canonical SMILES | C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
