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Cerulenin

Catalog No.
C4653
fatty acid synthase (FAS) inhibitor
Grouped product items
SizePriceStock Qty
5mg
$150.00
Ship with 5-10 days
10mg
$284.00
Ship with 5-10 days
50mg
$1,114.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Cerulenin (CAS 17397-89-6) is a natural small molecule inhibitor targeting fatty acid synthase (FAS), an enzyme essential for fatty acid biosynthesis. In rat aortic endothelial cells exposed to palmitic acid, treatment with cerulenin reduces inflammatory marker expression (IL-1β, TNFα, VCAM-1, IL-6) and restores nitric oxide production. In vivo studies using ob/ob mouse models demonstrate cerulenin-mediated reversal of hepatic steatosis, associated with decreased expression of PPARα/γ, reduced uncoupling protein 2 (UCP2), elevated hepatic ATP levels, and lower ROS production. Cerulenin serves as a useful tool in metabolic research, particularly investigating fatty acid synthesis and related metabolic diseases.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt223.3
Cas No.17397-89-6
FormulaC12H17NO3
Solubility≤20mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name2R,3S-epoxy-4-oxo-7,10-dodecadienamide
SDFDownload SDF
Canonical SMILESC/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Cerulenin