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Captopril

Catalog No.
A4078
ACE inhibitor
Grouped product items
SizePriceStock Qty
100mg
$53.00
In stock
500mg
$76.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Captopril is an inhibitor of Angiotensin-I-converting enzyme (ACE) with IC50 value of 6nM [1].

Captopril is an old drug with antihypertensive efficacy commonly used in the control of blood pressure. Captopril is found to be an ACE inhibitor in all species studied. Administration of captopril inhibits the pressor response to intravenously administered angiotensin I but not that induced by angiotensin II both in normal human beings and in conscious normotensive rabbits. Captopril is proven to be a useful alternative to combination antihypertensive therapy in

the patients with resistant hypertension [2].

Captopril is also found to have anticancer activity. It can significantly reduce tumor growth without toxicity in athymic mice bearing LNM35 human lung cells xenografts. It is proven that captopril affects cell growth through inducing apoptosis [3].

References:
[1] FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000 Nov;84
[2] Bravo EL, Tarazi RC. Converting enzyme inhibition with an orally active compound in hypertensive man. Hypertension. 1979 Jan-Feb;1(1):39-46.
[3] Attoub S, Gaben AM, Al-Salam S, Al Sultan MA, John A, Nicholls MG, Mester J, Petroianu G. Captopril as a potential inhibitor of lung tumor growth and metastasis. Ann N Y Acad Sci. 2008 Sep;1138:65-72.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt217.29
Cas No.62571-86-2
FormulaC9H15NO3S
Solubility≥21.7 mg/mL in DMSO; ≥105.2 mg/mL in EtOH with ultrasonic; ≥48.6 mg/mL in H2O with ultrasonic
Chemical Name1-(3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid
SDFDownload SDF
Canonical SMILESOC(C1CCCN1C(C(CS)C)=O)=O
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control