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Capsazepine

Catalog No.
A3279
TRPV1 ion channel antagonist
Grouped product items
SizePriceStock Qty
10mg
$76.00
In stock
50mg
$304.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Capsazepine (CAS 138977-28-3) is a synthetic antagonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, serving as a structural analog of capsaicin. It competitively inhibits capsaicin binding to TRPV1 receptors (IC50=562 nM), consequently preventing capsaicin-induced nociception. It also blocks voltage-activated calcium currents in sensory neurons (EC50=7.7 μM), inhibits TRPM8 channel responses to menthol (IC50=18 μM), and suppresses nicotinic acetylcholine receptors in rat trigeminal ganglia. Additionally, capsazepine sensitizes human colon cancer cells to TRAIL-induced apoptosis. It is widely utilized as a research tool for investigating TRPV1 channel functions.

Chemical Properties

StorageStore at -20°C
M.Wt376.9
Cas No.138977-28-3
FormulaC19H21ClN2O2S
Solubility≥18.85 mg/mL in EtOH with gentle warming; insoluble in H2O; ≥22 mg/mL in DMSO with gentle warming
Chemical NameN-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
SDFDownload SDF
Canonical SMILESC1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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