Capsazepine
Catalog No.
A3279
TRPV1 ion channel antagonist
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Capsazepine (CAS 138977-28-3) is a synthetic antagonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, serving as a structural analog of capsaicin. It competitively inhibits capsaicin binding to TRPV1 receptors (IC50=562 nM), consequently preventing capsaicin-induced nociception. It also blocks voltage-activated calcium currents in sensory neurons (EC50=7.7 μM), inhibits TRPM8 channel responses to menthol (IC50=18 μM), and suppresses nicotinic acetylcholine receptors in rat trigeminal ganglia. Additionally, capsazepine sensitizes human colon cancer cells to TRAIL-induced apoptosis. It is widely utilized as a research tool for investigating TRPV1 channel functions.
| Storage | Store at -20°C |
| M.Wt | 376.9 |
| Cas No. | 138977-28-3 |
| Formula | C19H21ClN2O2S |
| Solubility | ≥18.85 mg/mL in EtOH with gentle warming; insoluble in H2O; ≥22 mg/mL in DMSO with gentle warming |
| Chemical Name | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide |
| SDF | Download SDF |
| Canonical SMILES | C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
