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(-)-Bicuculline methiodide

Catalog No.
B7081
GABAA receptor antagonist
Grouped product items
SizePriceStock Qty
10mg
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50mg
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For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

(-)-Bicuculline methiodide (CAS: 40709-69-1) is an antagonist of the γ-aminobutyric acid-A (GABA_A) receptor, inhibiting GABA binding with an IC_50 of approximately 500 μM. GABA_A receptors are ligand-gated chloride ion channels mediating inhibitory neurotransmission in the central nervous system. In studies using chick cerebellar synaptic membranes, this enantiomer exhibited lower activity relative to the (+)-enantiomer. Additionally, in *C. elegans*, (-)-bicuculline methiodide helped demonstrate pharmacological distinctions between UNC-49 GABA receptors and mammalian GABA_A receptors. This compound is employed widely in neuropharmacological research exploring GABA receptor function and regulation.

Chemical Properties

Physical AppearanceYellow solid
StorageStore at RT
M.Wt509.3
Cas No.40709-69-1
FormulaC21H20INO6
Solubility<10.19mg/ml in H2O; <25.46mg/ml in DMSO
Chemical Name(S)-6,6-dimethyl-5-((R)-8-oxo-6,8-dihydro-[1,3]dioxolo[4,5-e]isobenzofuran-6-yl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide
SDFDownload SDF
Canonical SMILESO=C1O[C@H](C(C=C2)=C1C3=C2OCO3)[C@H](C4=C5)[N+](C)(C)CCC4=CC6=C5OCO6.[I-]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

(-)-Bicuculline methiodide