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ATB-343

Catalog No.
C4596
hybrid molecule of an H2S donor and the NSAID indomethacin
Grouped product items
SizePriceStock Qty
5mg
$232.00
Ship with 5-10 days
10mg
$414.00
Ship with 5-10 days
50mg
$1,812.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

ATB-343, also named as indomethacin, is an H2S-releasing derivative of indomethacin [1].

Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].

In vitro: Indomethacin enhanced the NK cell activity in vitro by blocking the prostaglandin production of monocytes [3].

In vivo: In rats, oral administration of ATB-343 significantly inhibited gastric prostaglandin synthesis and systemic COX-1 activity [1]. Indomethacin was a potent inhibitor of prostaglandin synthesis. Indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. Indomethacin in submicromolar concentrations inhibited cyclic AMP-dependent protein kinase and endogenous protein phosphorylation [4].

Clinical trials: Indomethacin has entered clinical trial in Alzheimer's disease [5].

References:
[1] Wallace J L.  Hydrogen sulfide-releasing anti-inflammatory drugs[J]. Trends in Pharmacological Sciences, 2007, 28(10): 501-505.
[2] Wallace J L.  Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[J]. Antioxidants & redox signaling, 2010, 12(9): 1125-1133.
[3] Pedersen B K, Oxholm P, Klarlund K.  Characterization of the in vivo and in vitro effects of indomethacin on human natural killer cell activity[J]. Allergy, 1986, 41(7): 532-536.
[4] Kantor H S, Hampton M.  Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase[J]. 1978.
[5] Rogers J, Kirby L C, Hempelman S R, et al.  Clinical trial of indomethacin in Alzheimer's disease[J]. Neurology, 1993, 43(8): 1609-1609.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt566.1
Cas No.1000700-26-4
FormulaC28H20ClNO4S3
Solubility≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name1-(4-chlorobenzoyl)-5-methoxy-2-methyl-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester-1H-indole-3-acetic acid
SDFDownload SDF
Canonical SMILESCOc1ccc2c(c1)c(CC(=O)Oc1ccc(cc1)c1ssc(=S)c1)c(C)n2C(=O)c1ccc(Cl)cc1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

ATB-343