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AS 101

Catalog No.
B7830
Immunomodulator
Grouped product items
SizePriceStock Qty
10mg
$219.00
Ship with 5-10 days
50mg
$921.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ammonium tri-chloro(dioxoethylene-O,O′-)tellurate (AS-101), an anti–IL-10 compound, is a nontoxic immunomodulator.

AS101 (0.5-2.5 μg/ml) decreased IL-10 production in a dose-dependent manner. Incubation of RMCL and RMC in the presence of AS101 gradually and significantly decreased mesangial cell proliferation [1]. AS101 (0.5 μg/ml, 1 μg/ml) decreased tyrosine phosphorylation and nuclear translocation of stat3 via inhibition of IL-10 [2]. AS-101 induced proliferation and IL-2 production by human lymphocytes and enhanced the production of IL-2 and colony-stimulating factor by mouse spleen cells. Systemically administration of AS-101 to mice mediated antitumour effects. AS-101 directly enhanced the ratio of OKT4 to OKT8-positive cells in cultured mononuclear cells from AIDS patients [3]. AS101 showed significant bone marrow (BM)-sparing effects and preventd hair loss in chemotherapy-treated patients, with minimal overall toxicity [4]. In mice subjected to cecal ligation and puncture (CLP), treatment with AS101 significantly increased survival of septic mice. AS101 treatment restored the ability of these cells to secrete TNF-α and IL-1β. AS101 increased class II Ag expression on peritoneal macrophages. AS101 increased the level of IFN-γ secreted by splenocytes [5].

References:
[1] Kalechman Y, Sredni B, Weinstein T, et al.  Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101[J]. Journal of the American Society of Nephrology, 2003, 14(3): 620-630.
[2] Kalechman Y, Gafter U, Weinstein T, et al.  Inhibition of Interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis ASSOCIATION WITH DEPHOSPHORYLATION OF STAT3[J]. Journal of Biological Chemistry, 2004, 279(23): 24724-24732.
[3] Sredni B, Caspi R R, Klein A, et al.  A new immunomodulating compound (AS-101) with potential therapeutic application[J]. Nature, 1987, 330(6144): 173-176.
[4] Sredni B, Albeck M, Tichler T, et al.  Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[J]. Journal of Clinical Oncology, 1995, 13(9): 2342-2353.
[5] Kalechman Y, Gafter U, Gal R, et al.  Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[J]. The Journal of Immunology, 2002, 169(1): 384-392.

Chemical Properties

Physical AppearanceWhite crystalline solid
StorageStore at -20°C
M.Wt312.05
Cas No.106566-58-9
FormulaC2H4Cl3O2Te·NH4
SolubilitySoluble in DMSO
Chemical NameAmmonium trichloro[1,2-ethanediolato-O,O']-tellurate
SDFDownload SDF
Canonical SMILESC1CO[Te](O1)(Cl)(Cl)Cl.[NH4+]
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

AS 101