Toggle Nav

Allopregnanolone

In stock
Catalog No.
B7456
GABAA receptor positive allosteric modulator
Grouped product items
SizePriceStock Qty
5mg
$113.00
In stock
10mg
$166.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Allopregnanolone is a selective activator of GABA-A receptor with the concentration of 10 nM [1].
GABA-A receptor is a pentameric transmembrane receptor and sits in the membrane of neuron. As a subtype of receptor for the neurotransmitter GABA, GABA-A receptor mediates the bulk of synaptic inhibition in the central nervous system and prevents action potential generation by short-circuiting the depolarization produced by excitatory neurotransmission. It has been shown that allopregnanolone can directly activate GABA-A receptor and it also can allosteric enhance GABA-evoked currents to function [2] [1].
Allopregnanolone is an agonist for GABA-A receptor. When tested with rat retinas exposed to hydrostatic pressure (75 mm Hg) for 24 hours, administration of alloprenanolone significantly suppressed pressure-induced axonal swelling via functioning on GABA-A R in a dose-dependent manner [1].
In spinal cord slides from naïve rats, pre-incubation with TGOT significantly lower the following allopregnanolone (0.11 ± 0.04 ng/mg) treatment thus decayed GABA-A R which resulted in the spinal neurosteroidogenesis [3].
It is also reported that subcutaneously injected allopregnanolone to male Wistar rats once daily over five consecutive days resulted in energy intake and weight gain increasement [4].
References:
[1].    Ishikawa, M., et al., Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model. Invest Ophthalmol Vis Sci, 2014. 55(12): p. 8531-41.
[2].    Maguire, J. and I. Mody, Steroid hormone fluctuations and GABA(A)R plasticity. Psychoneuroendocrinology, 2009. 34 Suppl 1: p. S84-90.
[3].    Juif, P.E., et al., Long-lasting spinal oxytocin analgesia is ensured by the stimulation of allopregnanolone synthesis which potentiates GABA(A) receptor-mediated synaptic inhibition. J Neurosci, 2013. 33(42): p. 16617-26.
[4].    Holmberg, E., et al., Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet. Physiol Behav, 2015. 140: p. 1-7.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt318.49
Cas No.516-54-1
FormulaC21H34O2
SolubilitySoluble in DMSO
Chemical Name1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
SDFDownload SDF
Canonical SMILESO[[email protected]]1C[[email protected]]2[[email protected]@](CC1)(C)[[email protected]@H]3[[email protected]@H](CC2)[[email protected]]4[[email protected]]([[email protected]@H](C(C)=O)CC4)(C)CC3
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control