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Acetyl Angiotensinogen (1-14), porcine
Angiotensinogen precursor

Acetyl Angiotensinogen (1-14), porcine

Catalog No. A1034
Size Price Stock Qty
5mg $45.00 In stock
10mg $75.00 In stock
25mg $105.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Acetyl Angiotensinogen (1-14), porcine

Acetyl Angiotensinogen (1-14), porcine Dilution Calculator

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Chemical Properties

Cas No. 66641-26-7 SDF Download SDF
Synonyms Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C
Formula C87H125N21O21 M.Wt 1801.05
Solubility Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

Acetyl Angiotensinogen (1-14),porcine, (C87H125N21O21) is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH, MW= 1801.05. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. Pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure(1). The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia(2). Mutations in the gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.

A1034_1

Figure1  Formula of Acetyl Angiotensinogen (1-14),porcine

 A1034_2

Figure2  The renin–angiotensin–aldosterone system

Ref:

1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.

2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.