6-Hydroxydopamine hydrobromide

6-Hydroxydopamine hydrobromide (CAS: 636-00-0), commonly referred to as 6-OHDA hydrobromide, is a catecholamine-derived neurotoxin frequently used in neuroscience research to induce selective dopaminergic neuronal degeneration. Upon administration, it generates intracellular reactive oxygen species (ROS), activating apoptotic pathways via caspase-3, -8, and -9, as demonstrated in PC12 cell studies. In rodent models, targeted injection into substantia nigra, striatum, or medial forebrain bundle leads to loss of tyrosine hydroxylase-positive neurons and resultant locomotor dysfunction, resembling symptoms observed in Parkinson’s disease. Consequently, it serves as a valuable tool for elucidating dopaminergic dysfunction mechanisms and evaluating therapeutic candidates.