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6-Hydroxydopamine hydrobromide

Catalog No.
B7099
neurotoxin that destroys dopaminergic and noradrenergic (catecholaminergic) neurons
Grouped product items
SizePriceStock Qty
50mg
$50.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

6-Hydroxydopamine hydrobromide (CAS: 636-00-0), commonly referred to as 6-OHDA hydrobromide, is a catecholamine-derived neurotoxin frequently used in neuroscience research to induce selective dopaminergic neuronal degeneration. Upon administration, it generates intracellular reactive oxygen species (ROS), activating apoptotic pathways via caspase-3, -8, and -9, as demonstrated in PC12 cell studies. In rodent models, targeted injection into substantia nigra, striatum, or medial forebrain bundle leads to loss of tyrosine hydroxylase-positive neurons and resultant locomotor dysfunction, resembling symptoms observed in Parkinson’s disease. Consequently, it serves as a valuable tool for elucidating dopaminergic dysfunction mechanisms and evaluating therapeutic candidates.

Product Citation

Chemical Properties

StorageDesiccate at -20°C
M.Wt250.09
Cas No.636-00-0
FormulaC8H11NO3·HBr
Solubilityinsoluble in EtOH; ≥25 mg/mL in DMSO with ultrasonic; ≥45.4 mg/mL in H2O
Chemical Name5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide
SDFDownload SDF
Canonical SMILESOC(C(CCN)=C1)=CC(O)=C1O.Br
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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