6-Hydroxydopamine hydrobromide
6-Hydroxydopamine hydrobromide (CAS: 636-00-0), commonly referred to as 6-OHDA hydrobromide, is a catecholamine-derived neurotoxin frequently used in neuroscience research to induce selective dopaminergic neuronal degeneration. Upon administration, it generates intracellular reactive oxygen species (ROS), activating apoptotic pathways via caspase-3, -8, and -9, as demonstrated in PC12 cell studies. In rodent models, targeted injection into substantia nigra, striatum, or medial forebrain bundle leads to loss of tyrosine hydroxylase-positive neurons and resultant locomotor dysfunction, resembling symptoms observed in Parkinson’s disease. Consequently, it serves as a valuable tool for elucidating dopaminergic dysfunction mechanisms and evaluating therapeutic candidates.
Storage | Desiccate at -20°C |
M.Wt | 250.09 |
Cas No. | 636-00-0 |
Formula | C8H11NO3·HBr |
Solubility | insoluble in EtOH; ≥25 mg/mL in DMSO with ultrasonic; ≥45.4 mg/mL in H2O |
Chemical Name | 5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide |
SDF | Download SDF |
Canonical SMILES | OC(C(CCN)=C1)=CC(O)=C1O.Br |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure

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