In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide containing 7 glucopyranose units, with an average of one hydroxypropyl group per unit. The circular arrangement of the glucose units forms a torus-shaped ring configuration, and CH2 groups and ether linkages of the molecule face the hollow interior of the configuration, which leads to a nonpolar cavity and a polar exterior. When a compound with appropriate geometry and 2-hydroxypropyl-β-cyclodextrin are in the same solution, the nonpolar aromatic parts of that compound tend to interact with the nonpolar interior of the 2-hydroxypropyl-β-cyclodextrin molecule. This complexation isolates the aromatic parts of that compound from the water, thereby increasing its aqueous solubility. 2-Hydroxypropyl-β-cyclodextrin has been widely used in improving the aqueous solubility of a variety of compounds, especially those containing a phenyl group, a group encompassing many drugs.
1. Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. International Research Journal of Pharmacy, 2012, 3(1): 52-56.
2. Shewale BD, Sapkal NP, Raut NA, et al. Effect of hydroxylpropyl-β-cyclodextrin on solubility of carvedilol. Indian Journal of Pharmaceutical Sciences, 2008, 70(2): 255-257.
|Physical Appearance||A crystalline solid|
|Storage||Store at RT|
|Solubility||≥24.9 mg/mL in EtOH; ≥42 mg/mL in DMSO; ≥47 mg/mL in H2O|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|