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Catalog No.
A cyclic oligosaccharide widely used to improve the aqueous solubility of a variety of compounds
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2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide containing 7 glucopyranose units, with an average of one hydroxypropyl group per unit. The circular arrangement of the glucose units forms a torus-shaped ring configuration, and CH2 groups and ether linkages of the molecule face the hollow interior of the configuration, which leads to a nonpolar cavity and a polar exterior. When a compound with appropriate geometry and 2-hydroxypropyl-β-cyclodextrin are in the same solution, the nonpolar aromatic parts of that compound tend to interact with the nonpolar interior of the 2-hydroxypropyl-β-cyclodextrin molecule. This complexation isolates the aromatic parts of that compound from the water, thereby increasing its aqueous solubility. 2-Hydroxypropyl-β-cyclodextrin has been widely used in improving the aqueous solubility of a variety of compounds, especially those containing a phenyl group, a group encompassing many drugs. 


1. Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. International Research Journal of Pharmacy, 2012, 3(1): 52-56.

2. Shewale BD, Sapkal NP, Raut NA, et al. Effect of hydroxylpropyl-β-cyclodextrin on solubility of carvedilol. Indian Journal of Pharmaceutical Sciences, 2008, 70(2): 255-257.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
Cas No.128446-35-5
Solubility≥24.9 mg/mL in EtOH; ≥42 mg/mL in DMSO; ≥47 mg/mL in H2O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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