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E3 Ligase

E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.

product-structure
  1. Cat.No. Product Name Information
  2. B7727 NSC 624206 Ubiquitin-activating enzyme (E1) inhibitor
  3. B5797 PRT 4165 Bmi1/Ring1A-mediated ubiquitination inhibitor
  4. B5567 SMER 3 yeast SCF family E3 ubiquitin ligase (SCFMet30) inhibitor
  5. B7745 SZL P1-41 Skp2 inhibitor

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