Spleen Tyrosine Kinase (Syk)
Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.
" to show IC50
to view the IC50 value.- Cat.No. Product Name Information
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B3553
GS-9973
GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2.
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A8661
MNS
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation).
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A8546
R406
R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development.
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A8332
R788 disodium
R788 (prodrug of R406;Fostamatinib Disodium Hexahydrate) is part of a new class of rheumatoid arthritis drugs that blocks syk kinase, which can trigger the inflammation that is a hallmark of RA, thereby stopping the progression of the disease.
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A3228
BAY 61-3606 dihydrochloride
BAY 61-3606 dihydrochloride
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A3227
BAY 61-3606
BAY 61-3606 is a selective and orally available inhibitor of spleen tyrosine kinase (syk) with IC50 value of 10nM [1].
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N2031
Piceatannol
Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol by cytochrome P450 1B1.
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B6161
PRT-060318
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B6158
RO9021
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A5880
R406 (free base)
R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development.
