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Spleen Tyrosine Kinase (Syk)

Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

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  1. Cat.No. Product Name Information
  2. B3553 GS-9973 GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2.
  3. A8661 MNS Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation).
  4. A8546 R406 R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development.
  5. A8332 R788 disodium R788 (prodrug of R406;Fostamatinib Disodium Hexahydrate) is part of a new class of rheumatoid arthritis drugs that blocks syk kinase, which can trigger the inflammation that is a hallmark of RA, thereby stopping the progression of the disease.
  6. A3228 BAY 61-3606 dihydrochloride BAY 61-3606 dihydrochloride
  7. A3227 BAY 61-3606 BAY 61-3606 is a selective and orally available inhibitor of spleen tyrosine kinase (syk) with IC50 value of 10nM [1].
  8. N2031 Piceatannol Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol by cytochrome P450 1B1.
  9. B6161 PRT-060318
  10. B6158 RO9021
  11. A5880 R406 (free base) R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development.

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